Two elderly patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while. exantema y prurito. La toxicidad neurológica, aunque rara, es más frecuente tras la administración de Imipenem/Cilastatina. La aparición de convulsiones con. Incidence Most antibiotics are CNS-safe, and neurotoxicity associated with their administration is infrequent There have been anecdotal.

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Our website uses cookies to enhance your experience. No cause was found in 1 case. Surprisingly, in series with larger groups of patients, 913 no seizures caused by toxic-metabolic factors were observed. Neurological complications of acquired immunodeficiency syndrome: No complex partial seizures were observed.

The risk of seizures among the carbapenems: a meta-analysis.

Thus, in contrast to other authors, 14 we did not find a relationship between status epilepticus and poor outcome. Hypomagnesemia can induce epileptic seizures, 2728 and Van Paesschen et al 8 emphasize metabolic causes as important in HIV-infected patients.

Examination included testing glucose and serum electrolyte levels, liver and renal function, blood cell count, serologic tests for Toxoplasma gondii and cytomegalovirus, computed tomographic or magnetic resonance imaging brain scans, and, if required, toxicologic screens, electroencephalographic and cerebrospinal fluid studies biochemical tests, serologic tests for syphilis and T gondii, Gram stain, cultures for Cryptococcus neoformans and Umipenemstains for acid-fast Bacillusand polymerase chain reaction for herpes simplex virus.


Purchase access Subscribe now. Register for email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts. No serious adverse effects were observed in patients who received phenytoin, except in 1 patient with ataxia and nystagmus because the dosage omipenem too high.

Metabolic derangements hypoglycemia and hypomagnesemia were observed in 2 patients The cause of seizures in 2 patients was hypoglycemia and hypomagnesemia. N Engl J Med. Prior to their first seizure, 14 patients convulsionnes Any patient with a first seizure during this 1-year period was examined by physicians from the Department of Neurology and followed up quarterly until death or study end.

Enferm Infecc Microbiol Clin.

Since the number of HIV-infected patients with first seizure in our study is relatively low, seizure characterization is limited. In the literature, seizures have been reported as a presenting manifestation of HIV-related disease in 3.

We were able to identify the cause of seizure in Seizures were refractory to therapy in 3 patients Seizures directly related to substance use, abuse, and withdrawal are increasingly common. First seizure in adults: A cause was identified in most of our patients Neurotoxicity due to use of zidovudine has been long recognized as a cause of epileptic seizures.

The risk of seizures among the carbapenems: a meta-analysis.

Sign in to save your search Sign in to your personal account. All 17 patients had a generalized seizure at some time.

Privacy Policy Terms of Use. Sign in to access your subscriptions Sign in to your personal account. At the time of first seizure, 14 Patients who had seizures responded well to therapy.


The HIV stage was less advanced in those with no identifiable cause than in those with an identifiable cause. In 1 patient, imipenem produced a Convulsiobes seizure, a well-known adverse effect.

imipendm Create a free personal account to download free article PDFs, sign up for alerts, and more. In our series, we were unable to identify a presumed cause in only 1 patient in whom the HIV infection alone was the presumed cause. A third patient had a GTC seizure related to medazepam hydrochloride treatment withdrawal. We studied patients both outpatients convulsilnes inpatients for only 1 year; if the inclusion period had been longer, the occurrence might have been higher.

HIV-related encephalitis presenting as convulsant disease. One patient had simple partial seizures imipene, PML. The cause of 1 partial seizure dysphasiawhich evolved to a generalized seizure, was hypomagnesemia. Create a free personal account to access your subscriptions, sign up for alerts, and more. Seizure after zidovudine overdose. Get free access to newly published articles Create a personal account or sign in to: Carbamazepine therapy was discontinued in both patients because of adverse effects severe skin reaction and ataxia and was changed to phenytoin.